Fat Cells and Inflammatory Overload

There is now substantial literature suggesting that fat cells contribute greatly to systemic inflammation.  This appears to be one of the mediating links between obesity and a number of chronic conditions including chronic pain, metabolic syndrome, type II diabetes, coronary artery disease, heart disease, stroke and dementia.  Modifying the body mass index (BMI) has long been linked to health benefits, but the new research gives us a way to understand why this is so important.  Eating a wide variety of antioxidant rich fruits and vegetables, along with concentrated and balanced antioxidant supplementation, appears to be wise and safe from the perspective of today’s science. [1-17]

1.    Zeyda, M., et al., Inflammation Correlates With Markers of T-Cell Subsets Including Regulatory T Cells in Adipose Tissue From Obese Patients. Obesity (Silver Spring), 2010.

2.    Yang, H., et al., Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol, 2010. 185(3): p. 1836-45.

3.    Tkacova, R., Systemic inflammation in chronic obstructive pulmonary disease: may adipose tissue play a role? Review of the literature and future perspectives. Mediators Inflamm, 2010. 2010: p. 585989.

4.    Sell, H. and J. Eckel, Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes. Curr Opin Clin Nutr Metab Care, 2010. 13(4): p. 366-70.

5.    Ostertag, A., et al., Control of adipose tissue inflammation through TRB1. Diabetes, 2010. 59(8): p. 1991-2000.

6.    Maury, E. and S.M. Brichard, Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol, 2010. 314(1): p. 1-16.

7.    Ikeoka, D., J.K. Mader, and T.R. Pieber, Adipose tissue, inflammation and cardiovascular disease. Rev Assoc Med Bras, 2010. 56(1): p. 116-21.

8.    Hauner, H., Adipose tissue inflammation: are small or large fat cells to blame? Diabetologia, 2010. 53(2): p. 223-5.

9.    Gustafson, B., Adipose tissue, inflammation and atherosclerosis. J Atheroscler Thromb, 2010. 17(4): p. 332-41.

10.    Gonzalez-Periz, A. and J. Claria, Resolution of adipose tissue inflammation. ScientificWorldJournal, 2010. 10: p. 832-56.

11.    Gauthier, M.S. and N.B. Ruderman, Adipose tissue inflammation and insulin resistance: all obese humans are not created equal. Biochem J, 2010. 430(2): p. e1-4.

12.    Wajchenberg, B.L., et al., Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis. Arq Bras Endocrinol Metabol, 2009. 53(2): p. 145-50.

13.    Vachharajani, V. and D.N. Granger, Adipose tissue: a motor for the inflammation associated with obesity. IUBMB Life, 2009. 61(4): p. 424-30.

14.    Shwarts, V., [Adipose tissue inflammation and atherosclerosis]. Kardiologiia, 2009. 49(12): p. 80-6.

15.    Sakurai, T., et al., Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue. Biochem Biophys Res Commun, 2009. 379(2): p. 605-9.

16.    Qatanani, M., et al., Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J Clin Invest, 2009.

17.    Pasarica, M., et al., Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes, 2009. 58(3): p. 718-25.

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