Anti-oxidants and Suicide?

The effect if oxidative stress in the brain has been linked to dementia[1], depression[2, 3] and now suicide attempts[4]. According to a study published in Nutritional Neuroscience, a study of nearly 7000 individuals with mental health diagnoses, those who attempted suicide had significantly lower levels of critical antioxidants than those who did not.  Could this study be the beginning of an evidence base supporting the recommendation of anti-oxidant supplementation for depressed patients with suicidal ideation?

1.    Aliev, G., et al., Antioxidant therapy in Alzheimer’s disease: theory and practice. Mini Rev Med Chem, 2008. 8(13): p. 1395-406.

2.    Maes, M., et al., Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry, 2010.

3.    Maes, M., et al., A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry, 2010.

4.    Li, Y. and J. Zhang, Serum concentrations of antioxidant vitamins and carotenoids are low in individuals with a history of attempted suicide. Nutr Neurosci, 2007. 10(1-2): p. 51-8.

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